The DETECT Study

PAH-SSc Findings

DETECT was a large, international, prospective, cross-sectional study funded and supported by Actelion Pharmaceuticals Ltd that sought to develop an algorithm to help assess risk of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc), or scleroderma, to optimize diagnostic right heart catheterization (RHC) and minimize missed PAH diagnoses. Sixty-two experienced centers across 18 countries performed RHCs on 466 patients with SSc at increased risk for PAH.¹*

PAH-SSc IS MORE COMMON THAN PREVIOUS STUDIES HAVE SUGGESTED^1-3
Nearly 1 in 5 patients with SSc (18.7%, 87/466) were found to have associated PAH via RHC¹

SCREENING OF PATIENTS WITH NONSYMPTOMATIC SSc CAN HELP EARLY DIAGNOSIS
PAH was mild in nearly two-thirds of patients with PAH-SSc (64%, 56/87): WHO FC I/II with moderately elevated mPAP and pulmonary vascular resistance and preserved mean cardiac index¹

PAH-SSc CAN PROGRESS QUICKLY
44% of patients with PAH-SSc with follow-up data (25/57) progressed during a short time (median observation time, 12.6 months)^4†

For more details about the DETECT study, read the publication from the Annals of the Rheumatic Diseases.

DETECT Algorithm

From 112 initial variables, 13 were selected based on their discriminatory ability to detect PAH and these variables formed the basis of the detection algorithm. Multivariable analysis resulted in 8 measures that together aid in the referral to RHC to identify PAH-SSc, even in patients with milder disease, while reducing missed diagnoses and unnecessary testing.¹

THE DETECT ALGORITHM 2-STEP DECISION TREE¹

Step 1

Nonechocardiographic
variables

TOTAL RISK
POINTS >300

• FVC % predicted/Dlco % predicted
• Current/past telangiectasias
• Serum anticentromere antibodies
• Serum NT-proBNP
• Serum urate
• Right-axis deviation on electrocardiogram

TOTAL RISK
POINTS >300

Step 2

Echocardiogram

TOTAL RISK
POINTS >35

• Right atrium area
• TR velocity

TOTAL RISK
POINTS >35

 

Referral
for RHC

The DETECT algorithm had a 4% (n=3) rate of missed PAH diagnoses compared with 29% (n=24) using the 2009 ESC/ERS Guidelines.¹

• Sensitivity and specificity analysis using the 408 SSc patients in the DETECT study (87 with RHC-confirmed PAH and 321 without)
• Exclusion of any single variable from the DETECT algorithm had only a small impact on model performance. If more than one variable is missing, the model cannot be used reliably

The DETECT study included patients with SSc who¹:

• Were 18 years or older
• Were diagnosed more than 3 years ago
• Had a predicted Dlco <60%

DETECT Video

Play the video below to learn how the DETECT screening tool helps identify patients with SSc who should be evaluated for PAH.

DETECT Screening Tool for PAH-SSc

The DETECT Screening Tool for PAH-SSc using the algorithm developed by Actelion Pharmaceuticals US, Inc., a Janssen Pharmaceutical Company, and validated in the DETECT study is available for download to your iPhone and Android devices. It can help you identify patients with SSc who should be evaluated for PAH using electrocardiography and may be in need of an RHC for confirmation of PAH-SSc.

The DETECT Screening Tool for PAH-SSc is limited for use by healthcare specialists who treat patients with SSc, and who are familiar with PAH as a complication of SSc. It is not intended to replace the medical or professional judgment of healthcare providers. It does not provide professional advice and should not be considered a diagnosis. Healthcare professionals using the tool should exercise clinical judgment as to the information they provide to the patient based upon the tool.

A website-based version of the DETECT Screening Tool for PAH-SSc is also available. Go to DETECT Screening Tool Online Calculator >